I find it terribly frustrating when i have to use a computer mouse at the default speed. There is no good reason why i should have to move the mouse halfway across the desk and bend my wrist at uncomfortable angles just to move from one side of the screen to the other. Modern mouse lasers are really quite accurate and you can make the cursor go right across two full high def screens with maybe 8cm of desk space. Plus I normally increase the scroll wheel speed so i dont spend so long rolling the wheel to get to the bottom of message threads, emails and web pages.

Here are screenshots of some suggested speed settings.

Mouse motion at maximum speed:

And scroll wheel at about half maximum speed.